The overexpession of p53 protein was immunohistochemically studied in a total of 92 gastric carcinomas, of which 40 cases(43.5%) showed nuclear immunoreactivity. Older age(p<0.001), lymph node metastasis(p<0.05), stage(p<0.05), and higher
expression of
proliferating cell nuclear antigen(p<0.05) were correlated with p53 overexpression. Other clinicopathologic parameters including sex, tumor site, WHO classification, Ming classification, inflammation degree, desmoplasia degree, tumor invasion
depth,
gross type, size, and recurrence were not related with p53 overexpression. However, intestinal type(56.3%) by Lauren classification and advanced gastric carcinoma(48.0%) showed higher incidence of p53 overexpression than diffuse type(36.7%) and
early
gastric carcinoma(23.5%), respectively(0.05with
patients survival. We concluded that p53 overexpression was common event in gastric carcinogenesis and may play role not in late, invasive stage of tumor progression related with patient survival, but in early, proliferative stage of gastric
carcioma
progression.
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